I have seen a customer problem recently where the use of a virus scanner running over Caché databases was causing intermittent application slow downs and bad user response times.
This is a surprisingly common problem, so this short post is just a reminder to exclude key Caché components from your virus scanning.
Generally virus scanning must exclude the CACHE.DAT database files and Caché binaries. If an anti-virus is scanning CACHE.DATs and InterSystems files then system performance will be significantly impacted.