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Introduction

Earlier this year, I set about creating kit to introduce young techy folk at a Health Tech hackathon to using InterSystems IRIS for health, particularly focusing on using FHIR and vector search.

I wanted to publish this to the developer community because the tutorials included in the kit make a great introduction to using FHIR and to building a basic RAG system in IRIS. Its an all inclusive set of tutorials to show in detail how to:

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10:47 AM — Jose Garcia's creatinine test results arrive at the hospital FHIR server.
2.1 mg/dL — a 35% increase from last month.

What happens next?

  • Most systems: ❌ The result sits in a queue until a clinician reviews it manually — hours or days later.
  • This system: 👍 An AI agent evaluates the trend, consults clinical guidelines, and generates evidence-based recommendations — in seconds, automatically.

No chatbot. No manual prompts. No black-box reasoning.

This is event-driven clinical decision support with full explainability:

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Triggered automatically by FHIR events
Multi-agent reasoning (context, guidelines, recommendations)
Complete audit trail in SQL (every decision, every evidence source)
FHIR-native outputs (DiagnosticReport published to server)

Built with:
- InterSystems IRIS for Health — Orchestration, FHIR, persistence, vector search
- CrewAI — Multi-agent framework for structured reasoning

You'll learn: 🖋️ How to orchestrate agentic AI workflows within production-grade interoperability systems — and why explainability matters more than accuracy alone.

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How to set up RAG for OpenAI agents using IRIS Vector DB in Python

In this article, I’ll walk you through an example of using InterSystems IRIS Vector DB to store embeddings and integrate them with an OpenAI agent.

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One objective of vectorization is to render unstructured text more machine-usable. Vector embeddings accomplish this by encoding the semantics of text as high-dimensional numeric vectors, which can be employed by advanced search algorithms (normally an approximate nearest neighbor algorithm like Hierarchical Navigable Small World). This not only improves our ability to interact with unstructured text programmatically but makes it searchable by context and by meaning beyond what is captured literally by keyword.

In this article I will walk through a simple vector search implementation that Kwabena Ayim-Aboagye and I fleshed out using embedded python in InterSystems IRIS for Health. I'll also dive a bit into how to use embedded python and dynamic SQL generally, and how to take advantage of vector search features offered natively through IRIS.

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