TL;DR: This article demonstrates how to run GraphRAG-style hybrid retrieval—combining vector similarity, graph traversal, and full-text search—entirely within InterSystems IRIS using the iris-vector-graph package. We use a fraud detection scenario to show how graph patterns reveal what vector search alone would miss.

10:47 AM — Jose Garcia's creatinine test results arrive at the hospital FHIR server.
2.1 mg/dL — a 35% increase from last month.

What happens next?

• Most systems: ❌ The result sits in a queue until a clinician reviews it manually — hours or days later.
• This system: 👍 An AI agent evaluates the trend, consults clinical guidelines, and generates evidence-based recommendations — in seconds, automatically.

No chatbot. No manual prompts. No black-box reasoning.

This is event-driven clinical decision support with full explainability:

✅ Triggered automatically by FHIR events
✅ Multi-agent reasoning (context, guidelines, recommendations)
✅ Complete audit trail in SQL (every decision, every evidence source)
✅ FHIR-native outputs (DiagnosticReport published to server)

Built with:
- InterSystems IRIS for Health — Orchestration, FHIR, persistence, vector search
- CrewAI — Multi-agent framework for structured reasoning

You'll learn: 🖋️ How to orchestrate agentic AI workflows within production-grade interoperability systems — and why explainability matters more than accuracy alone.

Hey Developers,

Enjoy the new video on InterSystems Developers YouTube

⏯ Inside Vector Search - Technical Innovations In InterSystems IRIS @ READY 2025

https://www.youtube.com/embed/ofEfLqi-kU8
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Hey Developers,

Enjoy the new video on InterSystems Developers YouTube

⏯ First Customers Using Vector Search - Real World Experiences and Lessons Learned @ READY 2025

https://www.youtube.com/embed/HZrxAxrQges
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How to set up RAG for OpenAI agents using IRIS Vector DB in Python

In this article, I’ll walk you through an example of using InterSystems IRIS Vector DB to store embeddings and integrate them with an OpenAI agent.

One objective of vectorization is to render unstructured text more machine-usable. Vector embeddings accomplish this by encoding the semantics of text as high-dimensional numeric vectors, which can be employed by advanced search algorithms (normally an approximate nearest neighbor algorithm like Hierarchical Navigable Small World). This not only improves our ability to interact with unstructured text programmatically but makes it searchable by context and by meaning beyond what is captured literally by keyword.

In today’s healthcare data landscape, FHIR has become the standard for structured clinical data exchange. However, while FHIR excels at interoperability, its JSON format makes analytics challenging—including FHIR QuestionnaireResponse.

Introduction

In a previous article, I presented the IRIStool module, which seamlessly integrates the pandas Python library with the IRIS database. Now, I'm explaining how we can use IRIStool to leverage InterSystems IRIS as a foundation for intelligent, semantic search over healthcare data in FHIR format.

This article covers what I did to create the database for another of my projects, the FHIR Data Explorer. Both projects are candidates in the current InterSystems contest, so please vote for them if you find them useful.

You can find them at the Open Exchange:

• IRIStool and Data Manager
• FHIR Data Explorer

In this article we'll cover:

• Connecting to InterSystems IRIS database through Python
• Creating a FHIR-ready database schema
• Importing FHIR data with vector embeddings for semantic search

With the rapid adoption of telemedicine, remote consultations, and digital dictation, healthcare professionals are communicating more through voice than ever before. Patients engaging in virtual conversations generate vast amounts of unstructured audio data, so how can clinicians or administrators search and extract information from hours of voice recordings?

Hi Community,

We’re excited to share a brand-new Instruqt tutorial:

🧑‍🏫 RAG using InterSystems IRIS Vector Search

This hands-on lab walks you through building a Retrieval Augmented Generation (RAG) AI chatbot powered by InterSystems IRIS Vector Search. You’ll see how vector search can be leveraged to deliver up-to-date and accurate responses, combining the strengths of IRIS with generative AI.

✨ Why try it?

Hey Community,

We're excited to invite you to the next InterSystems UKI Tech Talk webinar:

👉AI Vector Search Technology in InterSystems IRIS

⏱ Date & Time: Thursday, September 25, 2025 10:30-11:30 UK

Speakers:
👨‍🏫 @Saurav Gupta, Data Platform Team Leader, InterSystems
👨‍🏫 @Ruby Howard, Sales Engineer, InterSystems

Customer support questions span structured data (orders, products 🗃️), unstructured knowledge (docs/FAQs 📚), and live systems (shipping updates 🚚). In this post we’ll ship a compact AI agent that handles all three—using:

• 🧠 Python + smolagents to orchestrate the agent’s “brain”
• 🧰 InterSystems IRIS for SQL, Vector Search (RAG), and Interoperability (a mock shipping status API)

Hey Community,

Last week, the InterSystems team held our monthly Developer Meetup in a new venue for the first time ever! In the AWS Boston office location in the Seaport, over 71 attendees showed up to chat, network, and listen to talks from two amazing speakers. The event was a huge success; we had a packed house, tons of engagement and questions, and attendees lining up to chat with our speakers afterwards!

Jayesh presents on Testing Frameworks for Agentic Systems to a full house