Interoperability on Python (IoP) is a proof-of-concept project designed to showcase the power of the InterSystems IRIS Interoperability Framework when combined with a Python-first approach.IoP leverages Embedded Python (a feature of InterSystems IRIS) to enable developers to write interoperability components in Python, which can seamlessly integrate with the robust IRIS platform. This guide has been crafted for beginners and provides a comprehensive introduction to IoP, its setup, and practical steps to create your first interoperability component. By the end of this article, you will get a clear understanding of how to use IoP to build scalable, Python-based interoperability solutions.