#InterSystems IRIS for Health

The third developer previews of InterSystems IRIS^® data platform, InterSystems IRIS^® for Health, and HealthShare^® Health Connect 2026.1 have been posted to the WRC developer preview site.  Containers can be found on our container registry and are tagged latest-preview.

These developer previews includes the dropping of Mac Intel support starting from 2026.1.0, and the adding back of Windows Server 2019 support to 2026.1.0.

Initial documentation can be found at these links below:

• InterSystems IRIS Data Platform 2026.1 | Documentation Home Page
• HealthShare Health Connect 2026.1 | Documentation

TL;DR This article explains how to deploy InterSystems IRIS Community Edition on Azure using the Azure Marketplace and a Virtual Machine. It covers prerequisites, instance selection, authentication, SSH access, first verification steps, and how to delete resources to avoid charges. The deployment can typically be done using Azure free credits and is suitable for developers who want to quickly start working with IRIS in the cloud.

Who this guide is for. This guide is intended for developers, solution architects, and DevOps engineers who want to deploy InterSystems IRIS Community Edition on Microsoft Azure. No prior Azure automation experience is required, but basic familiarity with the Azure Portal and SSH is helpful.

After following this guide, you will be able to:

• Launch InterSystems IRIS Community Edition from the Azure Marketplace
• Configure a small, secure Azure VM
• Connect to IRIS using SSH and the Management Portal
• Reset the default IRIS password and verify that IRIS is running

Prerequisites

• An active Azure subscription (new accounts may have free credits)
• Permissions to create resource groups, VMs, and networking resources
• An SSH client and a private key (.pem) you can store securely
• Basic knowledge of Linux command line

Deployment overview

• Open the IRIS Community Edition listing in Azure Marketplace and click Get it now
• In Azure Portal, choose Start with a pre-set configuration (or Create)
• Configure Basics: subscription, resource group, VM name, region, image, and size (a small VM is usually sufficient)
• Choose SSH key authentication and generate/download the key if needed
• Review + Create, accept terms, and deploy; then Go to resource → Connect → SSH
• First SSH login: run iris password to change _SYSTEM/SYS; start a session with iris session iris
• Management Portal: http://YOUR_VM_IP:52773/csp/sys/UtilHome.csp

10:47 AM — Jose Garcia's creatinine test results arrive at the hospital FHIR server. 2.1 mg/dL — a 35% increase from last month.

What happens next?

• Most systems: ❌ The result sits in a queue until a clinician reviews it manually — hours or days later.
• This system: 👍 An AI agent evaluates the trend, consults clinical guidelines, and generates evidence-based recommendations — in seconds, automatically.

No chatbot. No manual prompts. No black-box reasoning.

This is event-driven clinical decision support with full explainability:

✅ Triggered automatically by FHIR events ✅ Multi-agent reasoning (context, guidelines, recommendations) ✅ Complete audit trail in SQL (every decision, every evidence source) ✅ FHIR-native outputs (DiagnosticReport published to server)

Built with:

• InterSystems IRIS for Health — Orchestration, FHIR, persistence, vector search
• CrewAI — Multi-agent framework for structured reasoning

You'll learn: 🖋️ How to orchestrate agentic AI workflows within production-grade interoperability systems — and why explainability matters more than accuracy alone.

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Hey Community!

We're happy to share a new video from our InterSystems Developers YouTube:

⏯  Taking the Fear out of FHIR - Fast Tracking Organizational FHIR Readiness @ Ready 2025

In my previous HttpRequests, I have used Content-Type = application/json but I have a vendor that is requesting we send application/x-www-form-urlencoded. How would I go about formatting the Payload as x-www-form-urlencoded?

Thanks

RIP Neil Pappalardo

i am  install the IRISHealth on Mac,however,it met below error,can someone help on this issue:

below is the setup when do install,id/group irisusr is create during install setup.

Instance name: IRIS
Destination directory: /Users/xxx/Downloads/IRIS
IRISHealth version to install: 2025.3.0.226.0com
Installation type: Custom
Unicode support: Y
Initial Security settings: Normal
User who owns instance: xxx
Group allowed to start and stop instance: staff
Effective group for IRISHealth processes: irisusr
Effective user for IRISHealth SuperServer: irisusr
SuperServer port: 1972
WebServer port: 52773
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