Interesting anecdote I want to share. Not 100% Caché related, but I hope it would be useful.
When CSP Gateway is configured on IIS, opening CSP Gateway Configuration page is prohibited by default -- as IIS blocks URLs with '/bin' in it.
In our documentation we advise to add <remove segment="bin" /> to applicationHost.config file.
That is correct.
Recently I had problem when manual editing file Windows\System32\inetsrv\config\applicationHost.config has absolutely no effect on IIS.
Turned out (http://serverfault.com/a/599865) IIS was 64-bit and notepad++ that I used for editing was 32-bit.
So, notepad++ instead of saving original applicationHost.config file saved its copy to Windows\SysWOW64\inetsrv\Config and IIS did not see these changes