When developing a new Interoperability Production, it is quite natural that settings are initially added in the Production.
However, as soon as you want to move the Production from development to a test or staging environment, it becomes clear that some settings like HTTP Servers, IP addresses and/or ports need to be changed. In order to avoid these settings being overwritten during a redeployment later on, it is essential that you move these settings from the Production to the System Default settings.