If you plan on using the nginx server to front end you IRIS instance (as opposed to the standard apache web gateway install) you will need to add a few configuration options into the CSP.conf file in order for all urls to work. It took me a little bit to figure this out but this seems to be the configuration that works.

If you are using the container version of nginx from the Intersystems Container Registry you should use the %SYS persistent volume to store your CSP configuration and then utilize the ISC_CSP_CONF_FILE and ISC_CSP_INI_FILE environment variables to merge them into the running nginx instance.

location /csp/bin/Systems {
    CSPFileTypes cxw;
    CSPNSD_pass 127.0.0.1:7038;
    CSPNSD_response_headers_maxsize 8k;
    CSPNSD_connect_timeout 300s;
    CSPNSD_send_timeout 300s;
    CSPNSD_read_timeout 300s;
}
location /csp/bin/RunTime {
    CSPFileTypes cxw;
    CSPNSD_pass 127.0.0.1:7038;
    CSPNSD_response_headers_maxsize 8k;
    CSPNSD_connect_timeout 300s;
    CSPNSD_send_timeout 300s;
    CSPNSD_read_timeout 300s;
}
location /api {
    CSP ON;
    CSPNSD_pass 127.0.0.1:7038;
    CSPNSD_response_headers_maxsize 8k;
    CSPNSD_connect_timeout 300s;
    CSPNSD_send_timeout 300s;
    CSPNSD_read_timeout 300s;
}
location /csp/sys {
    CSP ON;
    CSPNSD_pass 127.0.0.1:7038;
    CSPNSD_response_headers_maxsize 8k;
    CSPNSD_connect_timeout 300s;
    CSPNSD_send_timeout 300s;
    CSPNSD_read_timeout 300s;
}
location /csp/healthshare {
    CSP ON;
    CSPNSD_pass 127.0.0.1:7038;
    CSPNSD_response_headers_maxsize 8k;
    CSPNSD_connect_timeout 300s;
    CSPNSD_send_timeout 300s;
    CSPNSD_read_timeout 300s;
}