I would add my 5 cents.
We have DeepSeeWeb projects which is Angular.js+gulp+Twitter Bootstrap thing.
It operates with DeepSee using MDX2JSON REST API.
You can see how it works e.g. in this GS Contest dashboard.
With Caché REST API and JSON as a transferring format for the data there a lot of pretty similar approaches for building UI:
React.JS, Angular2, Zen Mojo for web UI and .NET for the desktop.
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