Just came to my mind
- Cache-5.0.x is likely to be 32 Bit version, Win-11 is 64 Bit (only) (in case, the application uses some .dll, .ocx, etc.)
- unlikely that you use it, but as a hint, LAT is not supported anymore
- user database is now provided by ISC. In case your application maintains its own users, you can still use your own user database, but the login process will require some "adaption"

As a first step, I would contact your ISC Sales because Cache-5.0.x licenses neither work with (the latest) Cache nor with IRIS. Second, there was a lot of change between Cache-5.0.x and recent Cache/IRIS versions, so I would check to see if there are any problems to expect. A customer of mine "upgraded" fom Cache-5.0.21 to IRIS  some four years ago...

If your class is instantiable (i.e. not an abstarct class) then

set obj = ##class(MyPackage.MyClass).%New()
do obj.Main()
set x=obj.OtherMethod(parameter)

It seems, nobody likes the execute command... once celebrated, now frowned upon

set x="11,22,33,""Done"""
xecute "for i="_x_" write i,!"
11
22
33
Done

😏

I have a limited embedded python experience but if you can manage to get a (COS)%List from python then the solution is:

set $lb(val1, val2, val2, ...) = ConvertPythonTupelToCOSList(pythonfunction(param))
set $lb(val1, val2, val2, ...) = ConvertPythonListToCOSList(pythonfunction(param))

/// For example
ClassMethod Test()
{
  return $lb(11,22,33)
}

set $lb(a,b,c)=##class(Some.Class).Test()
write a,?5,b,?10,c ---> 11   22   33

I have no background information about your problem, but somehow I have the feeling, your have an organizational problem and not an isolational.

If one or more processes perform certain work under transaction and at the same time they feed a queue too ( I call it the WorkQueue) BEFORE the transaction is finished AND the queue is processed in parallel by an third process, then:
- either the third process (that with $order()) has to wait for the transaction to be finished or
- the process under transaction has to inform that third process about the outcome (i.e. rollback) of the transaction by feeding an second queue (I call this as the RolbackQueue).

The above implies, that
- before I put an item into the RollbackQueue, I would check, if it's already processed (from the WorkQueue), and if not, remove it from the WorkQueue and do not put it into the RollbackQueue
- in that third process, before processing an item, I would check, if that item is in the RollbackQueue. If yes, just do not process it (and remove from both queues)

As simple as that, merely I don't know your requirements.

A missing configuration is a good starting point... I think on Windows as well as on Linux, first you have to install the packages you are interested in, see here. Then you can import them.

It's not a "slight difference", it's a real difference, because you are using two different commands (a DO and an IF command)

set a = -1        // sets the variable a to -1
do $increment(a,1) zw "test" // increments <a> by 1, <a> is now 0
                             // the $increment() returns (the value of <a>)
                             // but the DO command do not expects a return value
                             // so the returned 0 is disposed
                             // hereinafter the next command on the line (zw) is executed
if $increment(a,1) zw "test" // increments <a> by 1, <a> is now 0
                             // the $increment() returns (the value of <a>) which is 0
                             // the IF command takes the returned value (0) but the value is
                             // "FALSE", hence the rest of the line is skipped (old style IF)
                             

If yo want to use the IF command and want both commands to be executed and have them on one line then:

// you have several options, a few of them
//
if $increment(a,1) { } zw "test" // empty IF-statement
if $increment(a,1)!1 zw "test"   // an IF with a forced outcome
if $increment(a,1)=a zw "test"   // if a=$increment(a,1) WON'T WORK !!!
//
// The only limit is only your imagination...

By the way, it's not a good idea using commands/functions with abbrevations and at the same time using mixed cases. In your examples I had to take a second look to realize, the one is a capital "i" and not a lowercase "L"

if $I(a,1) // increment a by 1
if $l(a,1) // return the subfieldcount from <a>, delimited by the character "1"

This works for me (pay attention to the semicolons!)

ClassMethod numpytest() As %String [ Language = python ]
{
 import numpy as np
 import math
 arr = np.array([1, 2, 3, 4, 5]); print(arr); x=np.random.randint(1, 15, 1) # generate a number between 1 and 15
 print("Random num=",x)
 y=math.pi
 print("This is pi:",y)
 x="hello world"
 print(x)
 a=2+5
 print("a=",a)
}

an the output is

USER>d ##class(Py.Demo).numpytest()
[1 2 3 4 5]
Random num= [13]
This is pi: 3.141592653589793
hello world
a= 7

USER>w $zv
IRIS for UNIX (Ubuntu Server LTS for x86-64) 2021.2 (Build 649U) Thu Jan 20 2022 08:49:51 EST
USER>

Just a small hint, if you have more than one statement on one line, separate them with a semicolon

print('one'); print('two') # this is OK
print('one') print('two')  # syntax error

On IRIS, long strings are enabled per default, you can check that

set x="", $e(x,3641144)="z"  // OK
set x="", $e(x,3641145)="z"  // <MAXSTRING> error

Just to see things clear, the size of a stream is limited by the size of the database (some GBs or even TBs) and the size of the storage media (hdd,sdd), whichever smaller is (less the size of other globals). The size of a table row (all fields together) is limited by the string size (either 32KB or 3.6MB). In a table row you can put a REFERENCE of a stream but not the stream itself.

Just a wild guess... somewhere some character type checkbox is checked or not checked? Maybe a wrong driver type (ASCII/Unicode)?

// For example, IRIS sends a username "paul" as a two byte sequence
0x70 0x00 0x61 0x00 0x75 0x00 0x6C 0x00

// the other end sees
0x70 - this is a 'p'
0x00 - C-type end of string (hence, the name is just 'p')

But as I said, it's just a guess...

Can you please ensure, my answer matches the original question? Thanks! Usually one makes a new question instead of changing an old question to a new one. Currently both my answers hang around without an context to the above question.