I'm not sure wha you want to achive, so I ask a puzzling question: do you want to create dungling object? "I want to remove the object from memory even if it is still referenced in memory", as I understand, would free the memory used by an object but let the object referenc(es) intact, so the reference now would point into nirvana. Is that what you want to do? Why? Can you a little bit elaborate, what is your target or the background respectively?

I have a limited embedded python experience but if you can manage to get a (COS)%List from python then the solution is:

set $lb(val1, val2, val2, ...) = ConvertPythonTupelToCOSList(pythonfunction(param))
set $lb(val1, val2, val2, ...) = ConvertPythonListToCOSList(pythonfunction(param))

/// For example
ClassMethod Test()
  return $lb(11,22,33)

set $lb(a,b,c)=##class(Some.Class).Test()
write a,?5,b,?10,c ---> 11   22   33

I have no background information about your problem, but somehow I have the feeling, your have an organizational problem and not an isolational.

If one or more processes perform certain work under transaction and at the same time they feed a queue too ( I call it the WorkQueue) BEFORE the transaction is finished AND the queue is processed in parallel by an third process, then:
- either the third process (that with $order()) has to wait for the transaction to be finished or
- the process under transaction has to inform that third process about the outcome (i.e. rollback) of the transaction by feeding an second queue (I call this as the RolbackQueue).

The above implies, that
- before I put an item into the RollbackQueue, I would check, if it's already processed (from the WorkQueue), and if not, remove it from the WorkQueue and do not put it into the RollbackQueue
- in that third process, before processing an item, I would check, if that item is in the RollbackQueue. If yes, just do not process it (and remove from both queues)

As simple as that, merely I don't know your requirements.

It's not a "slight difference", it's a real difference, because you are using two different commands (a DO and an IF command)

set a = -1        // sets the variable a to -1
do $increment(a,1) zw "test" // increments <a> by 1, <a> is now 0
                             // the $increment() returns (the value of <a>)
                             // but the DO command do not expects a return value
                             // so the returned 0 is disposed
                             // hereinafter the next command on the line (zw) is executed
if $increment(a,1) zw "test" // increments <a> by 1, <a> is now 0
                             // the $increment() returns (the value of <a>) which is 0
                             // the IF command takes the returned value (0) but the value is
                             // "FALSE", hence the rest of the line is skipped (old style IF)

If yo want to use the IF command and want both commands to be executed and have them on one line then:

// you have several options, a few of them
if $increment(a,1) { } zw "test" // empty IF-statement
if $increment(a,1)!1 zw "test"   // an IF with a forced outcome
if $increment(a,1)=a zw "test"   // if a=$increment(a,1) WON'T WORK !!!
// The only limit is only your imagination...

By the way, it's not a good idea using commands/functions with abbrevations and at the same time using mixed cases. In your examples I had to take a second look to realize, the one is a capital "i" and not a lowercase "L"

if $I(a,1) // increment a by 1
if $l(a,1) // return the subfieldcount from <a>, delimited by the character "1"

This works for me (pay attention to the semicolons!)

ClassMethod numpytest() As %String [ Language = python ]
 import numpy as np
 import math
 arr = np.array([1, 2, 3, 4, 5]); print(arr); x=np.random.randint(1, 15, 1) # generate a number between 1 and 15
 print("Random num=",x)
 print("This is pi:",y)
 x="hello world"

an the output is

USER>d ##class(Py.Demo).numpytest()
[1 2 3 4 5]
Random num= [13]
This is pi: 3.141592653589793
hello world
a= 7

USER>w $zv
IRIS for UNIX (Ubuntu Server LTS for x86-64) 2021.2 (Build 649U) Thu Jan 20 2022 08:49:51 EST

Just to see things clear, the size of a stream is limited by the size of the database (some GBs or even TBs) and the size of the storage media (hdd,sdd), whichever smaller is (less the size of other globals). The size of a table row (all fields together) is limited by the string size (either 32KB or 3.6MB). In a table row you can put a REFERENCE of a stream but not the stream itself.

Just a wild guess... somewhere some character type checkbox is checked or not checked? Maybe a wrong driver type (ASCII/Unicode)?

// For example, IRIS sends a username "paul" as a two byte sequence
0x70 0x00 0x61 0x00 0x75 0x00 0x6C 0x00

// the other end sees
0x70 - this is a 'p'
0x00 - C-type end of string (hence, the name is just 'p')

But as I said, it's just a guess...

If you process thousands of time splits,  it's a good idea using %List or just a simple %String instead of JSON - you can have a time savings by factor of about 10!

/// old line
set res=[]
for t=t(0):int:t(1) do res.%Push($zdt(t\86400_","_(t#86400),3,1))
quit res

/// new line
set res=""
for t=t(0):int:t(1) set res=res_$lb($zdt(t\86400_","_(t#86400),3,1))
quit res

/// or
set res=""
for t=t(0):int:t(1) set res=res_","_$zdt(t\86400_","_(t#86400),3,1)
quit $e(res,2,*)

To see the differences, try loops like this

/// with JSON
s h=$zh f i=1:1:1E5 { s r=[] f j=1:1:10 { d r.%Push("abcd") } } w $zh-h,!

/// with %List
s h=$zh f i=1:1:1E6 { s r="" f j=1:1:10 { s r=r_$lb("abcd") } } w $zh-h,!

/// with %String
s h=$zh f i=1:1:1E6 { s r="" f j=1:1:10 { s r=r_","_"abcd" } } w $zh-h,!
/// start, end: timestamp format
/// int       : the interval in seconds
/// mod       : 0 = use the time value as is
///            +1 = round-up the timestamp to a multiple of <int>
///            -1 = round-down the timestamp to a multiple of <int>
/// return an JSON array: [time1, time2, ... timeN]
ClassMethod Intervals(start, end, int = 15*60, mod = 0) As %DynamicArray
    set res=[], t(0)=$zdth(start,3,1), t(1)=$zdth(end,3,1)
    for i=0,1 {
        set t(i)=t(i)*86400+$p(t(i),",",2) 
        if mod,t(i)#int { set t(i)=t(i)-(t(i)#int) set:mod>0 t(i)=t(i)+int }

    for t=t(0):int:t(1) do res.%Push($zdt(t\86400_","_(t#86400),3,1))
    quit res

You can edit (or enhance) the above code to give you all matching elements. Below I share a code with you where you can choose the result data type (%List or %String) and the result scope (all the matching elements or just the first match).

/// Find common items of two lists or in two delimited strings
/// (as used in a $piece-function)
/// itm1: first list (as %List or comma-delimited %String)
/// itm2: other list (as %List or comma-delimited %String)
/// ans : 0 = return a comma-delimited %String with the first match found
///       1 = return a comma-delimited %String with all matches found
///       2 = return a %List with the first match found
///       3 = return a %List with all matches found
/// return value: according to <ans> argument
/// Hint: the "$d(var)," part is only needed if the <itm1> argument is
///       of %List type and can contain an "undefined" element like the
///       second element in $lb(11,,33).
ClassMethod FindCommonItems(itm1, itm2, ans = 0)
    set ptr=0, res="", all=ans#2
    set:'$lv(itm1) itm1=$lfs(itm1) set:'$lv(itm2) itm2=$lfs(itm2)
    while $listnext(itm1,ptr,val) { if $d(val),$lf(itm2,val) { set res=res_$lb(val) quit:'all } }
    quit $s(ans<2:$lts(res), 1:res)

There arises two questions.

First, why do you use a class where the documentation starts with "This class is used internally to hold property/field values needed for computed fields"?
Another word for classes which are marked as "used internally" is, that this classes can be changed (altered in its behavior) without any notice or documentation in one of the next versions. That's definitelly not what you want.
Second, what is your real problem (where you think, it's only solvable by using that %Library.PropertyHelper class)? Can you post (and describe) your real problem?

Two notes to your (above) code

- first, if you use the iterator method on an object which can contain long strings (longer what IRIS can handle) then you must specify the thrid argument to the %GetNext() method too, i.e.

while iterator.%GetNext(.key, .value, "stream") { ... }

- second, if you know the name and location of a stream property in an JSON object, like in your case, then just grab the data without using an iterator:

try { set jsonobj = {}.%FromJSON(httprequest.HttpResponse.Data) } catch { jsonobj=0 }
if jsonobj, jsonobj.statusCode = 200 {
   set pdf=jsonobj.value.labReport.%Get("pdf",,"stream<base64")  // according to the picture you provided
   ... // do something with the pdf-stream

For another example, how to work with long strings see this thread.