Yes there is a way since I have seen it.

The ZLOAD and ZREMOVE commands are combined. Here is a sample I was sent.

showAdmins() n rs1,rs2,rc1,rc2,$NAMESPACE,user,adminrole,roles
  s rs1=##class(%ResultSet).%New("Security.Roles:List")
  d rs1.Execute("*","%Admin_Manage:U,%Admin_Operate:U,%Admin_Secure:U")
  f  s rc1=rs1.Next() q:rc1=0  d
  . s adminrole=rs1.Data("Name")
  . s rs2=##class(%ResultSet).%New("Security.Users:List")
  . d rs2.Execute("*",adminrole)
  . f  s rc2=rs2.Next() q:rc2=0  w rs2.Data("Name"),"|",rs2.Data("Roles"),!
d showAdmins

The host, storage and DB engine don't influence the gref count at all. Only what the code does.
If you do a set,kill or write that is a gref.
The host, storage and DB engine determine the limit of grefs per second.
Faster storage is always better.
More memory (larger global/routine buffer) is always better.
Faster cores are always better. More cores are better if there is work for them to do.
Newer versions of IRIS (DB engine) are always better.

GLOSTAT will give you some numbers

Vertical Scaling IRIS