Based on InterSystems IRIS Minimum Supported CPU Models this CPU change just affects AMD.
I wonder if the DataMove feature could be used.
That could be like the GBLOCKCOPY but without the downtime.
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Making the new IRIS 2025.3+ work might require adjusting the EVC setting of VMware.
https://knowledge.broadcom.com/external/article/313545/vmware-evc-and-cpu-compatibility-faq.html