1. Usually this indicates that the IRIS is sending an incomplete certificate chain
2. The fact that you can access IRIS SMP has nothing to do with the outgoing HTTPS request, which I assume you do with %Net.HttpRequest and using the SSL property that match the SSL config
3. I recommend accessing the https://myserver.com/api/gap/... from a browser and to check the certificate chain. Usually you will see 3 certificates (root CA, intermediate authority, the certificate itself) - you should put all those certificates (one after the other) in the PEM file that is configured in the SSL config in IRIS. Depending on the CA (which might be public, or company self-generated) you need to ask your sys admin
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