I was facing the same issue as Jerry faced when connecting IRIS to SQL server. My ODBC connection is configured to authenticate via windows authentication.

Configure IRIS ODBC connection with Windows authentication using a
 

How I fixed it for myself?

Root cause

• The SQL Server DSN was set to Windows Integrated Authentication.
• IRIS opens the ODBC connection via irisdb.exe, which runs under the IRIS Windows services’ logon account.
• My IRIS services were running as LocalSystem, so SQL saw the machine account<ORGNAME>\<ASSETID>$. SQL had no login for that identity → 18456 / 28000 “Login failed

In this tutorial, I will discuss how can you connect your IRIS data platform to sql server db  .

Prereq: 

• Have ODBC driver installed in your device. You can download it from here: Download ODBC Driver for SQL Server - ODBC Driver for SQL Server | Microsoft Learn. 
• Have SQL Server and IRIS installed in your device
• Have SQL Server connection Authentication enabled in SQL server