From the official documentation: 

The compact database operation is designed to run concurrently with normal database activity. The operation does consume some system resources, however, and may not complete if the system is under extremely high load. For these reasons, InterSystems recommends running this and other database reorganization operations (including compacting and defragmenting globals) during off-peak hours, and running only one such operation on a system at a time.

https://docs.intersystems.com/iris20241/csp/docbook/DocBook.UI.Page.cls?...