Hello Colin,
The locks are certainly concerning, particularly on mgr. Those files are generated by IRIS so other instances don't try to write to the same database.
If you open the iris.lck files in notepad++ or another app, do they list any data?
For example, mine list:
c:\intersystems\i4h251\mgr\
MYCOMPUTERNAME
If these are empty, you may be safe to remove them.
If IRIS is not running, then you can try moving those files out of their current directories and try starting the instance again to see if it gets farther.
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