Hello Colin, 

The locks are certainly concerning, particularly on mgr.  Those files are generated by IRIS so other instances don't try to write to the same database. 

If you open the iris.lck files in notepad++ or another app, do they list any data?  

For example, mine list:

c:\intersystems\i4h251\mgr\
MYCOMPUTERNAME

If these are empty, you may be safe to remove them.

If IRIS is not running, then you can try moving those files out of their current directories and try starting the instance again to see if it gets farther.

Hello Liu Bo, 

This is a pretty uncommon error that could be a bug or other deeper problem. Reaching out to ISC Support would probably be a good idea if you have a support contact.

If not, you could try to take a JDBC log. It could be that the %qlogging error is covering up another error:

https://docs.intersystems.com/iris20261/csp/docbook/DocBook.UI.Page.cls?KEY=BSQG_jdbc#BSQG_jdbc_logging

This would let you see if there's any other issue causing this error or at least show if you were getting far enough to call the JVM.