This week at Global Summit we announced extensions for Visual Studio Code that will provide Explorer, Editing, Debugging and Source Control for InterSystems IRIS, Cache and Ensemble.
Those at the GS conference we able to see all this being demonstrated at our partner pavilion booth. We expect these extensions to be available in a month or so.
And to answer the original question directly, I've been running Cache Studio on Linux Mint very successfully using Wine. There are one or two glitches but they are mainly cosmetic and not unusual with many complex applications that run under Wine.