This documentation shows how to connect and interact with IRIS using Python. Following this worked for me:
Using port 1972 per the example worked in my case but your installation may vary. It requires Python 3 (3.4+). When you download the Intersystems wheel file, make sure that the filename remains unchanged otherwise pip won't be able to install it.
Thanks Robert! I got it working. I just needed to set my port correctly. It was incorrectly set to 58772 which is what we use for making http connections. I changed it to 1972 and it worked.
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