See the documentation:
No, You doens't loose your persistant data. If you need to purge your data too, you need to create a trigger or implement callback method %OnDelete.
Using Triggers - Using InterSystems SQL - InterSystems IRIS Data Platform 2021.1Defining Callback Methods - Defining and Using Classes - InterSystems IRIS Data Platform 2021.1
That I have been know, ISC don't have native tool for data masking.
Look at this open source project, maybe help you.
GitHub - TheSoftwareHouse/fogger
I never been used this tool.
Cristiano José da Silva.
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