Good Day Murray;

Anything to look out for VMs hosting Ensemble Databases on vMware being part of VMware Site Recovery Manager
making use of vSphere Replication? Can it be alone be safely used to boot up the VM on the other site?

Regards;

Anzelem.

If you are certainly sure, you have restarted the instance and the OS space and new size  after startup (as seen in system management) portal don't match, a 'truncate' will release the OS space immediately. I've encountered same issue  and this is what i've done.

Alternatively, you can create your own separate database that you are able to manage yourself and mark the setting of Journal to 'No'. Then map all not so important globals to that DB.