I thought I would take a moment to add something I discovered on a windows IRIS upgrade to 2025.1. . . make sure if you are installing python run time on windows you choose custom installation all users . . . from docs:
On Microsoft Windows, if you find that the Python runtime library is located within your user directory, for example, C:\Users<username>\AppData\Local\Programs\Python\Python311, it indicates that you have installed Python for the current user only. InterSystems recommends installing Python for all users to avoid unexpected results.
and
Important:
On Microsoft Windows, if sys.path contains a directory that is within your user directory, such as C:\Users\<username>\\Local\Programs\Python\Python311, it indicates that you have installed Python for the current user only. InterSystems recommends installing Python for all users to avoid unexpected results.
And
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