Just a note that from JavaScript (Node.js / Bun.js), equivalent things can be also achieved when IRIS is abstracted through the gldsb package, both for old-school Globals and IRIS objects.  See https://github.com/robtweed/glsdb

Just to add: 

The mg-dbx-napi API connection option gives the highest performance (by orders of magnitude - close to native ObjectScript database access performance), but requires the JavaScript runtime (Node.js / Bun.js) to be on the same physical server as IRIS which may present resilience/security concerns for some

The mg-dbx-napi networked connection is slower (limited by network bandwidth) but most resilient and secure option: the JS runtime can reside on a physically separate server from IRIS.

mg-dbx-napi (https://github.com/chrisemunt/mg-dbx-napi) resolves all the issues you've identified for the ISC Node.js driver.  And it out-performs all other Node/Bun interfaces