Yes, this makes no difference at software level and should work exactly the same with RS422/485 as with RS232.
The difference is that with RS232 the hardware cable uses single-ended signals, with RS422/485 the cable uses differential signals. In addition, RS485 can transport signals over much longer cables and can talk to multiple devices connected to the same cable, in that case a protocol with device uid's is needed.
So Caché can talk in an identical way to a RS485 device, but the (software) protocol will probably be different.
You'll need also a hardware device (converter/bus driver) to convert the RS232 signals from your pc/server to RS485 differential signals.