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You can try this using EmergencyId mode. Stop IRIS and start with the parameter:

Linux

iris start IRIS EmergencyId=user,password

Windows

iris start IRIS /EmergencyId=user,password

User and password can be anything. This will be used for login.

Once logged in as this user by the terminal, you can use the ^SECURITY routine in the %SYS namespace to change the password of _SYSTEM.

Documentation (Temporary):

EmergencyId Mode

^SECURITY

Thanks Lucas Fernandes
Getting below error while running "iris start IRIS EmergencyId=user,password" command:

(29) unable to open registry key

You have to include a slash before EmergencyId :

iris start iris /EmergencyId=userA,pwB

Also, make sure that 'iris' is indeed your instance name (use 'iris all' to show all instances)

You have to include a slash before EmergencyId :

It depends on OS. In Linux there's no slash. Windows is with slash.

Now getting below error after specifying right instance name:

Startup failed:  (22) Instance properties definition file does not exist or is inaccessable:   EmergencyID=user,password Configuration IRISHealth. 

Can you show the output of 'iris all' ?

Which is your OS ?

Please find output and exact command. OS = Windows 10
 Thanks

Can you try again with the slash (since it is windows, you have to use the slash) :
iris start irishealth /EmergencyId=user,password

As @Danny Wijnschenk said, on Windows it needs to be /EmergencyId=.

There are a few more instructions in the Documentation,  like "Start a command prompt, running it as an administrator", etc.