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If ce/iris is started by ccontrol /iris start in systemd service context then it must to be stopped also in systemd context.
If one is used ccontrol/iris start directly there are consequences for system where init is systemd.
1 ce/iris processes are in cgroupv2 in user.slice hierarchy (more logical to have it in system.slice)
2 ce/iris processes are under systemd session and for example if /etc/systemd/logind.conf  KillUserProcesses=yes then after user logout and  user session destruction
sibling processes might get signal (default SIGTERM) and handler might do process exits.
Some ce/iris system daemons are terminated (mainly started by startup STU), some are not terminated (mainly control and those are forked from it).
Another thing is /etc/systemd/logind.conf  RemoveIPC=yes.
systemd might just remove ipc resources owned by cache instance resulting cache kernel is not working
correctly in very base stuff.
Shortly it is worth to reread man systemd-logind, man logind.conf, man loginctl.
Though systemd service wrapper for control/iris start is not quite consistent with direct use of ccontrol/iris start and systemd might lose correct service state but it never loses control on processes as being unix init process.
Direct usage of ccontrol/iris start|stop requires attention to logind.conf KillUserProcesses=no, RemoveIPC=no.
systemd service wrapper is worth to use as ccontrol/iris start|stop wrapper if system is managed by systemd.

I would use template variant.

cat /etc/systemd/system/isccache@.service

[Unit]
Description='isc cache'
After=network.target
#After=network-online.target

[Service]

# 1st way oneshot
Type=oneshot
RemainAfterExit=yes
# end of 1st way

# 2nd way forking
#PIDFile recommended but might be absent
# Type=forking
# end 2nd way 

ExecStart=ccontrol start %i
ExecStop=ccontrol stop %i quietly

[Install]
WantedBy=multi-user.target

<end>

examples
systemctl start isccache@201772B865
systemctl status isccache@201772B865

systemctl stop isccache@201772B865

systemctl enable isccache@201772B865
systemctl disable isccache@201772B865

if systemd ce/iris service state is wrong or ce/iris shutdown fails.
ccontrol force 201772B865
systemctl stop isccache@201772B865
now it is ok for 
systemctl start isccache@201772B865

ce=cache or ensemble
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