Thanks for the responds Dmitry, But i tried in C drive (Cache instance installed location) also. Facing same problem can't able to use $ZF and Pipes. I thought may be instance not having privilege to write on C drive, So tried cache instance location(C:/Intersystems/Ensemble/). But same issue.

Previously one of the server we faced the same problem but after restarted the Ensemble Service with full privilege using Log On. It started to  accept $ZF(-1) and Open cmd command.

I tried the same thing here, but this time i can't able to resolve it.

Thanks