Personally, I would definitely recommend using variant 1 with * . It seems to  me shorter, brighter and clearer.

I would not worry about the speed of evaluation *  (just feeling - certainly I have no numbers or proofs about performance).

If I am correct and remember well the ISC courses, the "global directory/list of global vectors" is held somewhere in memory  for each process while beeing in certain namespace. And therefore should be quickly evaluated.

Additionally, if you would need to add a new global in the future (such as qAuditS for streams), then the current definition will satisfy such need automatically and without updating the map table. However similar mapping for the different LIVE / TEST / EDU / CLONE / ... instances should always be done by scripts and automatically during the upgrade every instance.

Just some hints. I wrote a few helper functions for similar purposes.

MaskToPattern(mask,sw) ; mask with * and ? -> M pattern
 ; $$MaskToPattern^Idea.System.ZIF("ABC?D*") -> 1"ABC"1E1"D".E
 ; sw .. used for contains test (.E on both ends) : $$MaskToPattern^Idea.System.ZIF("ABC?D",1) -> .E1"ABC"1E1"D".E

and

MATCH(input,mask) ; matches input string against search mask

-> $$MATCH^Idea.System.ZIF("CSVZ","CST*")=0, $$MATCH^Idea.System.ZIF("CSVZ","CSV*")=1
MATCHOR(input,masklist) ; matches input string against list of search masks with OR condition (at least one)

-> $$MATCH^Idea.System.ZIF("CSVZ","CSV*,PF*")=1
MATCHAND(input,masklist) ; matches input string against list of search masks with AND condition (all must fit)

-> $$MATCH^Idea.System.ZIF("CSVZ","CSV*,PF*")=0

My implementation :

MaskToPattern(mask,sw) N pattern,char,pos S pattern="",char="" F pos=1:1:$L(mask) D
 . I $E(mask,pos)="*" S pattern=pattern_$S(char="":"",1:"1"""_char_"""")_".E",char="" Q
 . I $E(mask,pos)="?" S pattern=pattern_$S(char="":"",1:"1"""_char_"""")_"1E",char="" Q
 . S char=char_$E(mask,pos)
 S pattern=pattern_$S(char="":"",1:"1"""_char_""""),char="" S:$G(sw) pattern=".E"_pattern_".E"
 Q patternMATCH(input,mask) Q input?@$$MaskToPattern^Idea.System.ZIF(mask)MATCHOR(input,list) N ok,pie,mask S ok=0 F pie=1:1:$L(list,",") S mask=$P(list,",",pie) I mask'="",$$MATCH^Idea.System.ZIF(input,mask) S ok=1 Q
 Q okMATCHAND(input,list) N ok,pie,mask S ok=1 F pie=1:1:$L(list,",") S mask=$P(list,",",pie) I mask'="",'$$MATCH^Idea.System.ZIF(input,mask) S ok=0 Q
 Q ok