18+ experience with InterSystems products, in different sizes of projects, different countries, and different fields except for healthcare.
And by some reasons, there is no SQL support.
SSL Error for this driver does not really mean it's SSL ERROR, in most cases it could mean, that connection can't be established, from the first step. Check if port really available, you could try it by using some different tools, like DBeaver.
And unfortunately I can't recommend this driver you trying to use, it's unstable. May throw sigfault errors randomly and have other bugs. I would recommend using this driver instead, in most scenarios both are compatible, this one just more stable and predictible. And this driver used by lots of other Python projects, like SQLAlchemy, Django, irissqlcli, and more based on them.
Javascript support for IRIS is quite limited, and it includes async/await. But you can wrap all IRIS related stuff to promises, and it will work, kind of. There is a lot of work needed to be done on the driver side, to make it powerful in JavaScript.
At the moment, I'm working on TypeORM support for IRIS, the package not published yet, should finish this week. But mostly working, there are some samples provided, all of them working.
Please have a look. I'm looking forward to any feedback, and open to any suggestions about which JS library would need to get IRIS support next