Thanks for the information. I still have not got it to work but I believe the issue is because I am using Visual Studio 2017. If I understand correctly, this version does not use the registry. It may be that the Intersystems setup is not compatible with that version. I would have to try the setup with Visual Studio 2015, but my use is for a secondary tool in which I would prefer to try out Entity Framework with Cache. So I may not test it too soon.