In the modern digital age, securing applications, particularly those handling sensitive health data, is paramount. The confidentiality, integrity, and availability of such data are crucial, necessitating robust security measures. Two-factor authentication (2FA) stands out as a critical enhancement in safeguarding access, adding an extra layer of security beyond just passwords. Recognizing the significance of this feature, InterSystems provides built-in support for 2FA in its database solutions. This tutorial aims to guide you through the process of configuring two-factor authentication in your InterSystems environment, ensuring that your data remains secure and accessible only to authorized users.