What do you have already?
Did you configure ODBC DSN, DYLD_LIBRARY_PATH?
Some information about configuring ODBC, you can find here.
First of all I think you need iODBC installed on your mac.
then ODBC Caché drivers, with correct environment variable DYLD_LIBRARY_PATH, do not forget to relogin after the set variable.
As proof, that's possible to do it. Done with Caché 2018.1