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I guess it depends a little on what you mean by integrate.  I know of a customer that has an application on Dynamics and uses Ensemble to integrate with some back end systems.  Dynamics itself is very much tied it's data model.  If you want to call out to another system for data to use in Dynamics, I think you'll want to look into best practices from Microsoft.   But as a messaging platform, Ensemble should support most integration needs well.  If you have a specific protocol or standard in mind you might verify that it is available in the adapters that ship with Ensemble.