Thank you so much @Guillaume Rongier 
for your help and also for being patient with me. Now my project is running correctly you helped me to find a solution.

Thank you so much @Guillaume.Rongier 7183  I got it to connect Intersystems IRIS Database with quarkus and the project is running, also, the ORM is working because it created the table automatically
the only problem that I'm having now is  when I'm trying to call the method POST or GET  I'm getting the following message
415 Unsupported Media Type.
Also, I tried to change the quarkus.datasource.jdbc.url. by 
quarkus.datasource.reactive.url  but when I did that didn't work

I updated the project on GitHub maybe you can help me with this message error running my project
https://github.com/JoseAdemar/quarkus-project-with-intersystems-ris-data...

looking at his code I could see his project is a little bit different from mine. I'm using  panache orm
Example:

my Repository

@ApplicationScoped
public class ClientRepository  implements PanacheRepositoryBase<Client,Long>{

}

my Entity

@Data
@NoArgsConstructor
@EqualsAndHashCode(onlyExplicitlyIncluded = true)
@Entity
@Table(name = "tbl_client")
public class Client {

    @Id
    @GeneratedValue(strategy = GenerationType.IDENTITY)
    @EqualsAndHashCode.Include
    private Long id;

    
    @Size(max = 50)
    @Column(name = "first_name")
    private String firstName;

    
    @Size(max = 50)
    @Column(name = "last_name")
    private String lastName;
    
}

my Controller

@Path("/api/guests")
@Produces(MediaType.APPLICATION_JSON)
@Consumes(MediaType.APPLICATION_JSON)
public class ClientController {

    
private final ClientService clientService;
    
    public ClientController(ClientService clientService) {
        this.clientService = clientService;
    }

    @POST
    public Response createClient(@RequestBody Client client) {
        clientService.create(client);
        return Response.status(Status.CREATED).entity(client).build();
    }

}

This the link of my project on GitHub
https://github.com/JoseAdemar/quarkus-project-with-intersystems-ris-data...

Thank you so much!
I'm going to check the repository.

I tried this setup but  it didn't work 
using other databases, I can set up easily
I tried that but still, it's not working:
 

pom.xml

<dependency>
            <groupId>com.intersystems</groupId>
            <artifactId>intersystems-jdbc</artifactId>
            <version>3.2.0</version>
            <scope>system</scope>
            <systemPath>${project.basedir}/src/main/resources/intersystems-jdbc-3.2.0.jar</systemPath>
        </dependency>
        
        <dependency>
            <groupId>org.hibernate</groupId>
            <artifactId>hibernate-iris</artifactId>
            <version>1.0.0</version>
            <scope>system</scope>
            <systemPath>${project.basedir}/src/main/resources/hibernate-iris-1.0.0.jar</systemPath>
        </dependency>

application.properties

quarkus.datasource.db-kind=other 
quarkus.datasource.username=_system
quarkus.datasource.password=*
quarkus.datasource.reactive.url=jdbc:IRIS://localhost:1972/USER
quarkus.datasource.jdbc.driver=com.intersystems.jdbc.IRISDriver
quarkus.hibernate-orm.dialect=org.hibernate.dialect.InterSystemsIRISDialect

Thanks, @Guillaume Rongier 
I'm going to try following this project and if I get it 
I'm going to give you some feedback.

Guys, I still couldn't set up the Intersystems IRIS database on quarkus, does anyone has already done this to help me?

Thank you @Eduard Lebedyuk 
I download the jar files and added  but I didn't get to set up
it's not working.

Thank you @Dmitry Maslennikov 
I download the jar files but I didn't get to set up
it's not working.

Do you know how I can get the jar file?
I was looking to download
but I'm not getting much information

Thanks !!