Hi, for these concerns I always refresh my memory going to this vid:

InterSystems Webinar: Configuring a Web Server for IIS for Better Performance and Security

https://www.youtube.com/watch?v=luplow26i7c 

Some key URL's you may find helpful too (find the newer version according to your IRIS version):

CSP Gateway Configuration Guide:
 
Web Servers for Microsoft Windows
 
How to Set Up SSL on IIS 7